FRANK LYKO

Lab Profile

Division of Epigenetics

Epigenetic mechanisms regulate the interpretation of genetic information and adapt gene expression patterns to changing developmental or environmental contexts. Several epigenetic mechanisms have been identified so far, with DNA cytosine methylation representing the best-studied and possibly most relevant epigenetic mark. Our research focuses on understanding the biological function of cytosine methylation as a versatile epigenetic mark. Importantly, altered DNA methylation patterns represent one of the earliest and most consistent hallmarks of human cancers. We are using molecular approaches in combination with genome-wide epigenetic profiling technologies to analyze epigenetic alterations in premalignant lesions and during tumor formation. In this context, we are using single-cell approaches to identify the tumor cells-of-origin, with a particular focus on non-melanoma skin cancer and colon cancer.

  • epigenetics
  • DNA methylation
  • squamous cell carcinoma
  • colon cancer

Institution Name

Deutsches Krebsforschungszentrum

Institution Short Name

DKFZ

Institution Address

Im Neuenheimer Feld 580 Heidelberg, Germany

Institution Website

Team

Principal Investigator

Frank Lyko

Team Members

Günter Raddatz
Scientist
Email

Manuel Rodriguez-Paredes
Scientist
Email

Llorenc Sole Boldo
PhD student
Email