KURT SCHMOLLER

Lab Profile

Schmoller lab - Cell and Organelle Size Control

From whole animals to subcellular structures, size is a key property that is fundamentally linked to function. Accordingly, the size of cells is tightly controlled and spans many orders of magnitude, depending on species, environmental context and – in multicellular organisms – cell di­fferentiation. For example, the volume of human cells ranges from the 30 ?m3 sperm cell to the 100000 times larger oocyte. In addition to controlling size itself, cells must coordinate their size with the size of organelles and intracellular processes. Yet, our understanding of the underlying regulatory mechanisms is surprisingly poor. This can in part be attributed to the fact that size control is a highly stochastic process that is hard to study with traditional bulk methods. To overcome this challenge, we combine molecular cell biology approaches and microfluidics-based single-cell imaging with concepts of physical sciences and mathematical modelling to unravel how cells coordinate growth with protein- and organelle-homeostasis as well as cell division.

  • cell size
  • live-cell imaging
  • yeast
  • histone homeostasis
  • mitochondria biogenesis

Institution Name

Helmholtz Zentrum München

Institution Short Name

HMGU

Institution Address

Ingolstädter Landstr. 1
85764 Neuherberg, Germany

Institution Website

Team

Principal Investigator

Kurt Schmoller

Group Leader

Ingolstädter Landstr. 1
85764 Neuherberg

Tel.:+49 (0) 89 3187 49145