Lab Profile

Computational Modelling

We develop quantitative modells of signal transduction and gene regulation, with a focus on signalling in colon cancer. We use organoids, mass-cytometry, scRNA-seq to generate perturbation data on a single cell level, and generate models that allow us to quantitatively dissect the response of complex signalling in heterogenious tissues on perturbations by oncogenic mutations and/or drugs.

  • Data analysis and modelling
  • single-cell transcriptomics
  • CyTOF

Institution Name

Charite – Universitätsmedizin Berlin & IRI Life Sciences

Institution Short Name


Institution Address

Chariteplatz 1
10117 Berlin, Germany

Institution Website


Principal Investigator

Nils Blüthgen


IRI Life Sciences,
Haus 18, Phillipstr. 13,
10115 Berlin