We develop quantitative modells of signal transduction and gene regulation, with a focus on signalling in colon cancer. We use organoids, mass-cytometry, scRNA-seq to generate perturbation data on a single cell level, and generate models that allow us to quantitatively dissect the response of complex signalling in heterogenious tissues on perturbations by oncogenic mutations and/or drugs.
- Data analysis and modelling
Charite – Universitätsmedizin Berlin & IRI Life Sciences
Institution Short Name
Chariteplatz 110117 Berlin, Germany
IRI Life Sciences, Haus 18, Phillipstr. 13, 10115 Berlin