LARS DÖLKEN
Lab Profile
Dölken lab
We are interested in how herpesviruses manipulate the host cell environment and use these viruses as a tool to discover new regulatory mechanisms in cell biology and immunology. A particular focus is on cytomegalovirus and herpes simplex virus 1 infection. We employ a broad range of systems biology methodology and integrative bioinformatic analyses to study virus-host interactions. We previously developed metabolic RNA labeling approaches (4sU-tagging) to increase the temporal resolution of gene expression profiling. We now pioneered metabolic RNA labeling using 4sU for single cell sequencing (single cell thiol-(SH)-linked) nucleotide conversion sequencing, sc2RNA-seq). We collaborate with various other groups to apply sc2RNA-seq to other model systems and develop new bioinformatics tools for integrative data analysis.
- Herpesvirus-host interaction
- Viral immune evasion
- Metabolic RNA labeling at single cell level (sc2RNA-seq)
- Development of new computational approaches
- Bridging data-driven and mechanistic models
- Network biology for multi-omics data
Institution Name
University Würzburg
Institution Short Name
JMU
Institution Address
Versbacherstr. 7, 97078 Würzburg, Germany
Institution Website
Team
Principal Investigator
Lars Dölken
Chair of Virology
Institute for Virology and Immunobiology, Versbacherstr. 7, 97078 Würzburg, Germany
Tel.:+49 (0) 9313189781