Lab Profile

Dölken lab

We are interested in how herpesviruses manipulate the host cell environment and use these viruses as a tool to discover new regulatory mechanisms in cell biology and immunology. A particular focus is on cytomegalovirus and herpes simplex virus 1 infection. We employ a broad range of systems biology methodology and integrative bioinformatic analyses to study virus-host interactions. We previously developed metabolic RNA labeling approaches (4sU-tagging) to increase the temporal resolution of gene expression profiling. We now pioneered metabolic RNA labeling using 4sU for single cell sequencing (single cell thiol-(SH)-linked) nucleotide conversion sequencing, sc2RNA-seq). We collaborate with various other groups to apply sc2RNA-seq to other model systems and develop new bioinformatics tools for integrative data analysis.

  • Herpesvirus-host interaction
  • Viral immune evasion
  • Metabolic RNA labeling at single cell level (sc2RNA-seq)
  • Development of new computational approaches
  • Bridging data-driven and mechanistic models
  • Network biology for multi-omics data

Institution Name

University Würzburg

Institution Short Name


Institution Address

Versbacherstr. 7,
97078 Würzburg, Germany

Institution Website


Principal Investigator

Lars Dölken

Chair of Virology

Institute for Virology and Immunobiology,
Versbacherstr. 7,
97078 Würzburg, Germany

Tel.:+49 (0) 9313189781