Lab Profile

Quantitative single cell biology

We are exploring mechanisms of stem cell differentiation in health and disease utilizing single-cell methods, in particular single-cell RNA-seq. The lab is interested in the influence of the microenvironment on cell fate decision and applies high-resolution spatial gene expression quantification in situ to identify interacting cell types. A particular focus is on the role of gene expression noise during cell fate choice. We are currently studying cell types of the hematopoietic system in the bone marrow, immune cells, and of the liver. Our group is also developing novel computational methods for single-cell analysis in order to address the biological questions of interest.

  • algorithm development
  • single-cell RNA-seq
  • stem cells
  • immune cells
  • liver

Institution Name

Max Planck Institute for Immunobiology and Epigenetics

Institution Short Name


Institution Address

Stübeweg 51,
79108 Freiburg, Germany Freiburg, Germany

Institution Website


Principal Investigator

Dominic Grün

Research Group Leader

Tel.:+49 (0) 1791073352