SCOG Virtual Lecture Series
‘Recent Advances in Single Cell Omics’:
11. Jan Philipp Junker (MDC/BIMSB Berlin)

We are excited to announce the next speaker in our SCOG Virtual Lecture Series ‘Recent Advances in Single Cell Omics’: Jan Philipp Junker (MDC/BIMSB Berlin)

• Title: ‘Cellular drivers of injury response and regeneration in the adult zebrafish heart‘

  In contrast to the mammalian heart, the zebrafish heart has a high capacity for regeneration. After cryoinjury, which mimics aspects of myocardial infarction, the injured tissue undergoes a transient period of fibrosis3, during which the damaged heart muscle regenerates via dedifferentiation and proliferation of cardiomyocytes. Many pathways and factors involved in heart regeneration have been described, but the cellular drivers of regeneration, such as the transient cell types in the regenerative niche, remain largely unknown. Here, we dissected cell type diversity in the regenerating zebrafish heart by single cell transcriptomics and discovered a high complexity of cell types specifically among the non-muscle cells. Based on spatiotemporal information, we systematically identified potential cellular regulators of cardiomyocyte regeneration, including several fibroblast-like cell types that express pro-regenerative factors. We used high-throughput lineage tracing to determine the origin of cell types in the regenerative niche. We showed that the endocardium, like the epicardium, gives rise to several distinct fibroblast cell types, and found that this process is regulated by Wnt signalling. Our results reveal an unexpected functional specialization of fibroblast cell types during the regenerative process.

Further information on participation, the program and the application for a lecture can be found below.

Virtual lecture series ‘Recent Advances in Single Cell Omics’

• Biweekly event on Fridays at 9:30 am (CEST)

• 30 min presentation, followed by 15 min discussion / Q&A

Synopsis

The virtual lecture series includes biweekly presentations about current single cell research. In addition to selected presentations by invited guests, we would particularly like to offer SCOG partners a platform to present their work to the network (read below how to apply).

The program will be updated regularly (see schedule below).

Participation

The Virtual Lecture Series takes place via GoToWebinar. Please register in order to receive information on how to join the webinar. REGISTER HERE.

Apply for lecture 

We would kindly like to encourage the SCOG community not only to participate as an attendee but to present their work to the community. All contributions are welcome.

If you are a SCOG partner (PI/group leader) or member (Postdoc) and would like to give a talk during the lecture series, please APPLY BY COMPLETING THIS FORM.

Please note that a balanced representation of topics, institutes and gender will be ensured in the selection of applications.