Organizer

SCOG Management Team
Email
contact@singlecell.de
Website
https://www.singlecell.de/
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Location

Virtual Meeting

More Info

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Date

May 08 2020

Time

CEST
9:30 am - 10:15 am

Labels

SCOG event

SCOG Virtual Lecture Series ‘Recent Advances in Single Cell Omics’:
1. Fabian Theis (HMGU Munich)

We are excited to announce the SCOG Virtual Lecture Series ‘Recent Advances in Single Cell Omics’, which will be kicked off by SCOG coordinator Fabian Theis (HMGU Munich):
  • Friday May 8, 9:30 am (CEST)
  • Fabian Theis: ‘Computational challenges in building a Lung Cell Atlas and leveraging it to study SARS-CoV-2’:

    Broad commercial availability has enabled single-cell genomics to move from generating cell maps to cell atlases. In this context, the Human Cell Atlas as international endeavour across many labs aims to generate potentially spatially resolved single cell omics maps of all human tissue. We have been contributing to the Lung Cell Atlas, a project of more than 10 experimental and computational labs. On the computational side, integration of samples is challenging due to complex, often nested batch effects in the data, and while many data integration methods have been put forward for this task in recent years, it is unclear how to consistently proceed. In the first part of my talk, I will discuss how we setup and performed a larger-scale benchmarking for atlas-level data integration.In the second part, we applied this to the Lung Cell Atlas, and then leverage it to query expression of key SARS-CoV-2 entry genes across subjects and cell types together with the Human Cell Atlas Lung Biological Network.  In this first meta-analyses of scRNA-seq studies, we analyzed 1,176,683 cells from 282 samples and 164 donors, and were able to associate increased levels of ACE2, TMPRSS2, and CTSL in specific cell types with increasing age, male gender, and smoking, all of which are epidemiologically linked to COVID-19 susceptibility and outcomes. 

    Further information on participation, the program and the application for a lecture can be found below.

 


Virtual lecture series ‘Recent Advances in Single Cell Omics’

  • Biweekly event on Fridays at 9:30 am (CEST)
  • 30 min presentation, followed by 15 min discussion / Q&A
Synopsis
The virtual lecture series includes biweekly presentations about current single cell research. In addition to selected presentations by invited guests, we would particularly like to offer SCOG partners a platform to present their work to the network (read below how to apply).
The program will be updated regularly (see schedule below).
Participation
The Virtual Lecture Series via Zoom is open to the scientific public, registration is not required. JOIN ZOOM MEETING
Apply for lecture 
We would kindly like to encourage the SCOG community not only to participate as an attendee but to present their work to the community. All contributions are welcome.
If you are a SCOG partner (PI/group leader) and would like to give a talk during the lecture series, please APPLY BY COMPLETING THIS FORM.
Please note that a balanced representation of topics, institutes and gender will be ensured in the selection of applications.

Hourly Schedule

Friday 08 May 2020

9:30am - 10:15am
Leveraging the Lung Cell Atlas to study SARS-COV-2
Fabian Theis (HMGU Munich)

Friday 22 May 2020

9:30am - 10:15am
tbd
tbd

Friday 05 June 2020

9:30am - 10:15am
tbd
Ana Pombo (MDC Berlin)

Friday 19 June

9:30am - 10:15am
tbd
tbd

Friday 03 July

9:30am - 10:15am
tbd
tbd

Friday 17 July

9:30am - 10:15am
tbd
tbd

Friday 31 July

9:30am - 10:15am
tbd
tbd

Friday 14 August

9:30am - 10:15am
tbd
tbd

Friday 28 August

9:30am - 10:15am
tbd
tbd