Organizer

SCOG Management Team
Email
contact.scog@gmail.com
Website
https://www.singlecell.de/
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Location

Virtual Meeting

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Next Event

Date

Nov 06 2020

Time

CET
9:30 am - 10:15 am

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SCOG event

Virtual Lecture Series
‘Recent Advances in Single Cell Omics’:
12. Boyan Bonev (HPC/HMGU Munich)

We are excited to announce the next speaker in our SCOG Virtual Lecture Series ‘Recent Advances in Single Cell Omics’: Boyan Bonev (HPC/HMGU Munich)
  • Title: ‘Single-cell multiomics analysis reveals extensive epigenome remodeling during cortical development

    Despite huge advances in stem-cell, single-cell and epigenetic technologies, the precise molecular mechanisms that determine lineage specification remain largely unknown. Applying an integrative multiomics approach, e.g. combining single-cell RNA-seq, single-cell ATAC-seq together with cell-type-specific DNA methylation and 3D genome measurements, we systematically map the regulatory landscape in the mouse neocortex in vivo. Our analysis identifies thousands of novel enhancer-gene pairs associated with dynamic changes in chromatin accessibility and gene expression. We provide evidence that although epigenetic remodeling generally precedes transcriptional activation, true priming appears limited to a subset of lineage-determining enhancers. Notably, we reveal that enhancer-promoter contact frequency varies considerably despite overall cell-type specificity. Finally, our work suggests a so far unrecognized function of several key transcription factors as putative “molecular bridges”, facilitating the reorganization of chromatin landscape accompanying lineage specification in the brain.

Further information on participation, the program and the application for a lecture can be found below.

Virtual lecture series ‘Recent Advances in Single Cell Omics’

  • Biweekly event on Fridays at 9:30 am (CEST)
  • 30 min presentation, followed by 15 min discussion / Q&A
Synopsis
The virtual lecture series includes biweekly presentations about current single cell research. In addition to selected presentations by invited guests, we would particularly like to offer SCOG partners a platform to present their work to the network (read below how to apply).
The program will be updated regularly (see schedule below).
Participation
The Virtual Lecture Series takes place via GoToWebinar. Please register in order to receive information on how to join the webinar. REGISTER HERE.
Apply for lecture 
We would kindly like to encourage the SCOG community not only to participate as an attendee but to present their work to the community. All contributions are welcome.
If you are a SCOG partner (PI/group leader) or member (Postdoc) and would like to give a talk during the lecture series, please APPLY BY COMPLETING THIS FORM.
Please note that a balanced representation of topics, institutes and gender will be ensured in the selection of applications.

Hourly Schedule

Friday 08 May 2020

9:30am - 10:15am
Leveraging the Lung Cell Atlas to study SARS-COV-2
Fabian Theis (HMGU Munich)

Friday 22 May 2020

1pn - 1:45pm
Dissecting regulatory trajectories during embryonic development at single cell resolution
Eileen Furlong (EMBL Heidelberg)

Friday 05 June 2020

9:30am - 10:15am
Cell-type specialization in the brain is encoded by specific long-range chromatin topologies
Ana Pombo (MDC Berlin)

Friday 19 June

9:30am - 10:15am
Single Cell Omics on COVID-19 in DeCOI
Joachim L. Schultze (DZNE Bonn)

Friday 03 July

9:30am - 10:15am
Extracting mechanistic insight from single-cell and spatial transcriptomics
Julio Saez-Rodriguez (Heidelberg University)

Friday 17 July

10am - 10:45am
'Using spatially resolved transcriptomics to study early mammalian development'
John Marioni (EMBL-EBI/Sanger Institute Hinxton)

Friday 28 August

9:30am - 10:15am
Single-cell decoding of gene regulatory programs
Uwe Ohler (MDC/BISMB Berlin)

Friday 11 September

9:30am - 10:15am
Revealing Dynamics of Gene Expression Variability in Cell State Space
Dominic Grün (MPI-IE Freiburg)

Friday 25 September

9:30am - 10:15am
Ageing and metabolic function: dissecting one cell at a time
Celia P. Martinez-Jimenez (HPC/HMGU Munich)

Friday 09 October

9:30am - 10:15am
tbd
Prisca Liberali (FMI Basel)

Friday 23 October

9:30am - 10.15am
Cellular drivers of injury response and regeneration in the adult zebrafish heart
Jan Philipp Junker (MDC/BIMSB Berlin)

Friday 06 November

9:30am - 10.15am
Single-cell multiomics analysis reveals extensive epigenome remodeling during cortical development
Boyan Bonev (HPC/HMGU Munich)

Friday 04 December

10:00am - 10:45am
Single cell multi-omics and spatial transcriptomics of mammalian development
Wolf Reik (Babraham Institute Cambridge)