SCOG Virtual Lecture Series
‘Recent Advances in Single Cell Omics’:
3. Ana Pombo (BIMSB/MDC Berlin)

We are excited to announce the next speaker in our SCOG Virtual Lecture Series ‘Recent Advances in Single Cell Omics’: Ana Pombo (BIMSB/MDC Berlin).

• Friday June 5, 9.30 am (CEST)

• Ana Pombo: ‘Cell-type specialization in the brain is encoded by specific long-range chromatin topologies’:
  Neurons are terminally differentiated cells that perform highly specialized functions, undergoing dynamic activation which depends on cascades of gene activation and subsequent downregulation to retain homeostatic control. Gene expression is regulated by how the genome is organised in three-dimensions (3D), from local levels of chromatin compaction to the organisation of topological domains and chromosome compartments. Here, we applied Genome Architecture Mapping (GAM) in the murine brain to map the 3D genome topology of dopaminergic neurons from the midbrain, glutamatergic neurons from the hippocampus, and oligodendrocyte lineage cells from the cortex. We integrate 3D genome organisation with gene expression obtained from single cell RNA-seq and identify cell-type specific changes in long-range chromatin structures that relate with specific patterns of gene expression, including extensive changes in compartment organisation, reorganisation of topological domains, and ‘TAD melting’ at highly active long neuronal genes. Our work shows that the 3D organisation of the genome is highly dynamic and essential to better understand neuronal-specific mechanisms of gene regulation.

Further information on participation, the program and the application for a lecture can be found below.

Virtual lecture series ‘Recent Advances in Single Cell Omics’

• Biweekly event on Fridays at 9:30 am (CEST)

• 30 min presentation, followed by 15 min discussion / Q&A

Synopsis

The virtual lecture series includes biweekly presentations about current single cell research. In addition to selected presentations by invited guests, we would particularly like to offer SCOG partners a platform to present their work to the network (read below how to apply).

The program will be updated regularly (see schedule below).

Participation

The Virtual Lecture Series takes place via GoToWebinar. Please register in order to receive information on how to join the webinar. REGISTER HERE.

Apply for lecture 

We would kindly like to encourage the SCOG community not only to participate as an attendee but to present their work to the community. All contributions are welcome.

If you are a SCOG partner (PI/group leader) and would like to give a talk during the lecture series, please APPLY BY COMPLETING THIS FORM.

Please note that a balanced representation of topics, institutes and gender will be ensured in the selection of applications.