SCOG Management Team



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Sep 06 2023


4:00 pm - 4:45 pm


SCOG event

Virtual Lecture Series
‘Recent Advances in Single Cell Omics’:
55. Céline Vallot (Institut Curie)

We are excited to announce the next speaker of our SCOG Virtual Lecture Series ‘Recent Advances in Single Cell Omics’: Céline Vallot (Institut Curie).


Mechanisms of cell plasticity in breast cancer
The dynamic nature of chromatin and transcriptional features are expected to participate to tumor evolution. Our group focuses on the study of the dynamics of histone modifications in cancer cells upon cancer treatment as well as during the initial steps of tumorigenesis. We develop experimental and computational approaches to map histone marks at single-cell resolution, enabling the investigation of the dynamics of chromatin marks in tumor samples (Grosselin et al. Nat Genet 2019; Prompsy et al. Nat Comm 2020).
We have recently combined single-cell epigenomic and transcriptomic approaches to lineage tracing strategies to reveal the initial epigenomic events driving tolerance to chemotherapy in triple-negative breast cancer (Marsolier & Prompsy et al., Nat Genet 2022). We show that the repressive histone mark H3K27me3 is a lock to the activation of a drug-persistent expression program in breast cancers. Under chemotherapy, very few cells can survive the treatment, and these cells have a remodeled repressive epigenome, with targeted loss at key promoters. Using demethylase inhibitor in combination to chemotherapy, we improve the response rate and delay recurrence both in vitro and in vivo.
We also study mechanisms of cell plasticity in early breast tumorigenesis in vivo. We have recently mapped state transitions during Brca1-tumorigenesis in the mouse. We discovered that luminal progenitor cells undergo a partial epithelial to mesenchymal transition at the onset of tumorigenesis (Landragin &Saichi, unpublished 2022).
Further information on participation, the program and the application for a lecture can be found below.
  • Further Information:


    VIRTUAL LECTURE SERIES: 'Recent Advances in Single Cell Omics'
    • Monthly event on Wednesdays at 4 pm (CEST)
    • 30 min presentation, followed by 15 min discussion / Q&A

    The virtual lecture series includes biweekly presentations about current single cell research. In addition to selected presentations by invited guests, we would particularly like to offer SCOG partners a platform to present their work to the network (read below how to apply).
    The program will be updated regularly (see schedule below).


    The Virtual Lecture Series takes place via Zoom. Please register in order to receive information on how to join the webinar. Your personal join link will be valid for all upcoming lectures of the series.


    We would kindly like to encourage the SCOG community not only to participate as an attendee but to present their work to the community. All contributions are welcome.
    If you are a SCOG partner (PI/group leader) or member (Postdoc) and would like to give a talk during the lecture series, please apply by completing the form on our website. Please note that a balanced representation of topics, institutes and gender will be ensured in the selection of applications.