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SCOG Management Team
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contact.scog@gmail.com
Website
https://www.singlecell.de/
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Location

Virtual

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Date

Jun 03 2022
Expired!

Time

CEST
9:30 am - 10:15 am

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SCOG event

SCOG Virtual Lecture Series
‘Recent Advances in Single Cell Omics’:
40. Florian Mair (ETH Zurich)

We are excited to announce the next speaker in our SCOG Virtual Lecture Series ‘Recent Advances in Single Cell Omics’: Florian Mair (Fred Hutchinson Cancer Research Center / ETH Zurich)

 

Abstract:
Disentangling human tumor-unique immune alterations from non-malignant tissue inflammation using multi-omic single cell analysis’

Immunotherapies to treat cancer have achieved remarkable successes, but major challenges persist. An inherent weakness of current treatment approaches is that therapeutically targeted pathways are not only found in tumors, but also in tissue microenvironments, particularly inflamed tissues. This confounding overlap complicates treatment as well as predictions of treatment outcome. In an effort to identify potential tumor-unique immunotherapeutic targets that are distinct from general tissue inflammation, we used complementary single-cell analysis approaches to interrogate immune cell alterations and interactions in human head and neck squamous cell carcinomas (HNSCC) and site matched non-malignant, inflamed oral tissues.
Using a combination of scRNA-sequencing and high-dimensional flow cytometry we found that a distinct population of intratumoral regulatory T cells (Tregs) is receiving T cell receptor (TCR) signals from antigen-presenting cells (APCs). This Treg population can be uniquely identified among all hematopoietic cells in the tumor by co-expression of ICOS and IL-1 receptor type 1 (IL-1R1), allowing therapeutic targeting and depletion by bispecific antibodies or logic-gated CAR T cells. In addition, we used targeted transcriptomics and protein profiling (AbSeq) to assess the functional response of these human intratumoral IL-1R1+ Tregs after stimulation via the T cell receptor or cytokines.
Overall, our work provides a blueprint for identifying tumor-unique therapeutic targets distinct from general inflammatory patterns in other tumors and reveals a possible strategy for specific depletion of intratumoral Tregs.

Biography:

Florian is currently working as Scientific Director of Cytometry and Senior Scientist Immunology at ETH Zurich, Switzerland. After graduating with a PhD in Molecular Life Sciences from the University of Zurich, Switzerland in 2014, he spent several years at the Fred Hutchinson Cancer Research Center in Seattle, USA. During the past decade, he has been involved extensively with different cytometry platforms (conventional, spectral and mass cytometry) as well as scRNA-sequencing techniques, including multi-omic methods. His main scientific interests are the function of dendritic cells and T cells in non-lymphoid tissues during health and disease.

Further information on participation, the program and the application for a lecture can be found below.
  • Further Information:

     

    VIRTUAL LECTURE SERIES: 'Recent Advances in Single Cell Omics'
    • Biweekly event on Fridays at 9:30 am (CEST)
    • 30 min presentation, followed by 15 min discussion / Q&A
    SYNOPSIS

    The virtual lecture series includes biweekly presentations about current single cell research. In addition to selected presentations by invited guests, we would particularly like to offer SCOG partners a platform to present their work to the network (read below how to apply).
    The program will be updated regularly (see schedule below).

    PARTICIPATION

    The Virtual Lecture Series takes place via Zoom. Please register in order to receive information on how to join the webinar. Your personal join link will be valid for all upcoming lectures of the series.
    REGISTER HERE

    APPLY FOR LECTURE

    We would kindly like to encourage the SCOG community not only to participate as an attendee but to present their work to the community. All contributions are welcome.
    If you are a SCOG partner (PI/group leader) or member (Postdoc) and would like to give a talk during the lecture series, please apply by completing the form on our website. Please note that a balanced representation of topics, institutes and gender will be ensured in the selection of applications.

    APPLY HERE

Hourly Schedule

11 February 2022

9:30 - 10:15
Andreas Moor (ETH Zurich)
Spatial biology in intestinal homeostasis and cancer

11 March 2022

9:30 - 10:15
Kikue Tachibana (MPIB Munich)
Insights into the emergence of 3D genome architecture at the start of life by single-nucleus Hi-C

25 March 2022

9:30 - 10:15
Bart Deplancke (EPFL Lausanne)
Engineering next-generation single cell phenomics technologies

08 April 2022

9:30 - 10:15
Christoph Bock (CeMM Vienna)
Looking into the past and future of cells: Single-cell analysis of epigenetic cell states in cancer and immunology

22 April 2022

9:30 - 10:15
Laleh Haghverdi (BIMS/MDC Berlin)
Towards reliable quantification of cell state velocities

06 May 2022

9:30 - 10:15
Christian Schmidl (LIT Regensburg)
Integrated single-cell profiling dissects cell-state-specific enhancer landscapes of human tumor-infiltrating T cells

20 May 2022

9:30 - 10:15
Heiko Lickert (HMGU Munich)
Deciphering mechanisms of beta cell development and regeneration

03 June 2022

9:30 - 10:15
Florian Mair (ETH Zurich)
Disentangling human tumor-unique immune alterations from non-malignant tissue inflammation using multi-omic single cell analysis

17 June 2022

9:30 - 10:15
Gabriela Salinas (UMG Göttingen)

01 July 2022

9:30 - 10:15
Kikuë Tachibana (MPIB Munich)
Insights into the emergence of 3D genome architecture at the start of life by single-nucleus Hi-C

15 July 2022

9:30 - 10:15
Elisabeth Binder (MPI of Psychiatry, Munich)