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SCOG Management Team
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https://www.singlecell.de/
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Location

Virtual

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Date

May 06 2022
Expired!

Time

CEST
9:30 am - 10:15 am

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SCOG event

SCOG Virtual Lecture Series
‘Recent Advances in Single Cell Omics’:
38. Christian Schmidl (LIT Regensburg)

We are excited to announce the next speaker in our SCOG Virtual Lecture Series ‘Recent Advances in Single Cell Omics’: Christian Schmidl (Leibniz Institute for Immunotherapy, Regensburg)

 

Abstract:

Integrated single-cell profiling dissects cell-state-specific enhancer landscapes of human tumor-infiltrating T cells

Despite extensive studies on the chromatin landscape of exhausted T cells, the transcriptional wiring underlying the heterogeneous functional and dysfunctional states of human tumor-infiltrating lymphocytes (TILs) is incompletely understood. Here, we identify tissue-specific and general gene-regulatory landscapes in the wide breadth of CD8+ TIL functional states covering four cancer entities using single-cell chromatin profiling. We map enhancer-promoter interactions in human TILs by integrating single-cell chromatin accessibility with single-cell RNA-seq data from tumor entity-matching samples, and prioritize key elements by super-enhancer analysis. Besides revealing entity-specific chromatin remodeling in exhausted TILs, our analyses identify a human core chromatin trajectory to TIL dysfunction and determine involved key enhancers, transcriptional regulators, and deregulated target genes in this process. Finally, we validate enhancer regulation at immunotherapeutically relevant loci by targeting non-coding regulatory elements with potent CRISPR activators and repressors. In summary, our study provides a framework for understanding and manipulating cell-state-specific gene-regulatory cues from human tumor infiltrating lymphocytes.

Biography:

Christian Schmidl obtained his PhD in 2013 at the University of Regensburg under the supervision of Michael Rehli where he studied DNA methylation patterns in lymphocytes. After that he joined the Research Center for Molecular Medicine (CeMM) in Vienna as a postdoc in Christoph Bock’s lab, where he developed and applied chromatin mapping methods to better understand molecular regulation of chronic lymphocytic leukaemia. In 2017, Christian took the opportunity to establishes his own research group at the Regensburg Center for Interventional Immunology (now Leibniz Institute for Immunotherapy), where he is studying gene-regulatory mechanisms in T cells in the context of cancer.

Further information on participation, the program and the application for a lecture can be found below.
  • Further Information:

     

    VIRTUAL LECTURE SERIES: 'Recent Advances in Single Cell Omics'
    • Biweekly event on Fridays at 9:30 am (CEST)
    • 30 min presentation, followed by 15 min discussion / Q&A
    SYNOPSIS

    The virtual lecture series includes biweekly presentations about current single cell research. In addition to selected presentations by invited guests, we would particularly like to offer SCOG partners a platform to present their work to the network (read below how to apply).
    The program will be updated regularly (see schedule below).

    PARTICIPATION

    The Virtual Lecture Series takes place via Zoom. Please register in order to receive information on how to join the webinar. Your personal join link will be valid for all upcoming lectures of the series.
    REGISTER HERE

    APPLY FOR LECTURE

    We would kindly like to encourage the SCOG community not only to participate as an attendee but to present their work to the community. All contributions are welcome.
    If you are a SCOG partner (PI/group leader) or member (Postdoc) and would like to give a talk during the lecture series, please apply by completing the form on our website. Please note that a balanced representation of topics, institutes and gender will be ensured in the selection of applications.

    APPLY HERE

Hourly Schedule

11 February 2022

9:30 - 10:15
Andreas Moor (ETH Zurich)
Spatial biology in intestinal homeostasis and cancer

11 March 2022

9:30 - 10:15
Kikue Tachibana (MPIB Munich)
Insights into the emergence of 3D genome architecture at the start of life by single-nucleus Hi-C

25 March 2022

9:30 - 10:15
Bart Deplancke (EPFL Lausanne)
Engineering next-generation single cell phenomics technologies

08 April 2022

9:30 - 10:15
Christoph Bock (CeMM Vienna)
Looking into the past and future of cells: Single-cell analysis of epigenetic cell states in cancer and immunology

22 April 2022

9:30 - 10:15
Laleh Haghverdi (BIMS/MDC Berlin)
Towards reliable quantification of cell state velocities

06 May 2022

9:30 - 10:15
Christian Schmidl (LIT Regensburg)
Integrated single-cell profiling dissects cell-state-specific enhancer landscapes of human tumor-infiltrating T cells

20 May 2022

9:30 - 10:15
Heiko Lickert (HMGU Munich)

03 June 2022

9:30 - 10:15
Florian Mair (ETH Zurich)
Disentangling human tumor-unique immune alterations from non-malignant tissue inflammation using multi-omic single cell analysis

17 June 2022

9:30 - 10:15
Gabriela Salinas (UMG Göttingen)

01 July 2022

9:30 - 10:15
Kikuë Tachibana (MPIB Munich)
Insights into the emergence of 3D genome architecture at the start of life by single-nucleus Hi-C

15 July 2022

9:30 - 10:15
Elisabeth Binder (MPI of Psychiatry, Munich)