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Date

Apr 08 2022
Expired!

Time

CET
9:30 am - 10:15 am

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SCOG event

SCOG Virtual Lecture Series
‘Recent Advances in Single Cell Omics’:
36. Christoph Bock (CeMM, Vienna)

We are excited to announce the next speaker in our SCOG Virtual Lecture Series ‘Recent Advances in Single Cell Omics’: Christoph Bock (CeMM, Vienna)

 

Abstract:

Looking into the past and future of cells: Single-cell analysis of epigenetic cell states in cancer and immunology

Most diseases develop through the complex interplay of genetic and environmental influences, involving signaling pathways, metabolic changes, immune deregulation, and diverse cellular phenotypes. Our research is based on the hypothesis that the “epigenetic landscape” constitutes a highly informative intermediate layer of information processing that allows cells to maintain their regulatory state and cellular identity over time, while retaining the flexibility to respond swiftly to a broad range of perturbations.

In our definition, the “epigenetic landscape” is not restricted to epigenetic marks such as DNA methylation and histone modifications. Rather, it reflects the full spectrum of transcription regulation by which cells translate various inputs into sustainable changes in their cell state. Notably, the epigenetic landscape not only reflects a cell’s current state, but also its developmental history (e.g., cell-of-origin in cancer) and its potential for future adaptation (e.g., plasticity in response to an immunological challenge).

I will present our work within and beyond the Human Cell Atlas, dissecting epigenetic cell states in immunology and cancer; and I will present methods for causal, mechanistic analysis at scale (CROP-seq and KPNNs) and for ultra-high throughput transcriptome profiling in millions of single cells (scifi-RNA-seq).

Funding: C.B. is supported by an ERC Consolidator Grant (n° 101001971) of the European Union.

Biography:

Christoph Bock is a Principal Investigator at the CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences and Professor of [Bio]Medical Informatics at the Medical University of Vienna. His research combines experimental biology (high-throughput sequencing, epigenetics, CRISPR screening, synthetic biology) with computational methods (bioinformatics, machine learning, artificial intelligence) – for cancer, immunology, and precision medicine (https://www.bocklab.org & https://twitter.com/BockLab). Before coming to Vienna, he was a postdoc at the Broad Institute of MIT and Harvard and a PhD student at the Max Planck Institute for Informatics. Christoph Bock is also scientific coordinator of the Biomedical Sequencing Facility of CeMM and MedUni Vienna, and he leads an EU Horizon 2020 project that contributes single-cell sequencing of organoids to the Human Cell Atlas. His research awards include the Otto Hahn Medal of the Max Planck Society, ERC Starting and Consolidator grants, the Overton Prize of the International Society for Computational Biology, and inclusion in the global list of “Highly Cited Researchers” by Clarivate Analytics (ISI Web of Science). He co-founded Aelian Biotechnology, a Vienna-based startup company that develops and applies single-cell methods for high-throughput biology and drug discovery.

Further information on participation, the program and the application for a lecture can be found below.
  • Further Information:

     

    VIRTUAL LECTURE SERIES: 'Recent Advances in Single Cell Omics'
    • Biweekly event on Fridays at 9:30 am (CEST)
    • 30 min presentation, followed by 15 min discussion / Q&A
    SYNOPSIS

    The virtual lecture series includes biweekly presentations about current single cell research. In addition to selected presentations by invited guests, we would particularly like to offer SCOG partners a platform to present their work to the network (read below how to apply).
    The program will be updated regularly (see schedule below).

    PARTICIPATION

    The Virtual Lecture Series takes place via Zoom. Please register in order to receive information on how to join the webinar. Your personal join link will be valid for all upcoming lectures of the series.
    REGISTER HERE

    APPLY FOR LECTURE

    We would kindly like to encourage the SCOG community not only to participate as an attendee but to present their work to the community. All contributions are welcome.
    If you are a SCOG partner (PI/group leader) or member (Postdoc) and would like to give a talk during the lecture series, please apply by completing the form on our website. Please note that a balanced representation of topics, institutes and gender will be ensured in the selection of applications.

    APPLY HERE

Hourly Schedule

11 February 2022

9:30 - 10:15
Andreas Moor (ETH Zurich)
Spatial biology in intestinal homeostasis and cancer

11 March 2022

9:30 - 10:15
Kikue Tachibana (MPIB Munich)
Insights into the emergence of 3D genome architecture at the start of life by single-nucleus Hi-C

25 March 2022

9:30 - 10:15
Bart Deplancke (EPFL Lausanne)
Engineering next-generation single cell phenomics technologies

08 April 2022

9:30 - 10:15
Christoph Bock (CeMM Vienna)
Looking into the past and future of cells: Single-cell analysis of epigenetic cell states in cancer and immunology

22 April 2022

9:30 - 10:15
Laleh Haghverdi (BIMS/MDC Berlin)
Towards reliable quantification of cell state velocities

06 May 2022

9:30 - 10:15
Christian Schmidl (LIT Regensburg)
Integrated single-cell profiling dissects cell-state-specific enhancer landscapes of human tumor-infiltrating T cells

20 May 2022

9:30 - 10:15
Heiko Lickert (HMGU Munich)

03 June 2022

9:30 - 10:15
Florian Mair (ETH Zurich)
Disentangling human tumor-unique immune alterations from non-malignant tissue inflammation using multi-omic single cell analysis

17 June 2022

9:30 - 10:15
Gabriela Salinas (UMG Göttingen)

01 July 2022

9:30 - 10:15
Kikuë Tachibana (MPIB Munich)
Insights into the emergence of 3D genome architecture at the start of life by single-nucleus Hi-C

15 July 2022

9:30 - 10:15
Elisabeth Binder (MPI of Psychiatry, Munich)