*CANCELED*: Keystone Symposium: Single Cell Biology- Pushing New Frontiers in the Life Sciences
This conference is co-organized by SCOG-founder Nikolaus Rajewsky and several SCOG partners are among the speakers.
Life has evolved profound heterogeneity of cells within a tissue, and the function of a tissue or organ can only be understood by understanding how these cells interact. Diseases often arise within a subset of cells within a tissue, or have different consequences in different cells. Thus, it is key to capture and interpret cellular heterogeneity. Recent technology advances are beginning to make multiplexed molecular analysis of millions of individual cells a reality. An emerging challenge is to connect these very rapidly evolving technical advances and “Big Data” to molecular mechanisms so that an understanding of cellular heterogeneity in health and disease (beyond description) emerges. The overall goal of the conference is to connect and synergize the “technical advance” community and the broader biology/medical community. Specifically, (i) to expose participants to cutting-edge techniques in single cell analysis and (ii) to provide a forum for researchers to share their work with colleagues and facilitate development of mutually beneficial collaborations. Several aspects of our proposed conference make it unique and of significant interest. One such aspect is our broader focus beyond the transcriptome of dissociated single cells as is common. Our proposal encompasses analysis of the epigenome, proteome, lipidome and metabolome of single cells in a dissociated state and, more importantly, in situ, preserving crucial spatial information. Additionally, our proposed conference uniquely has a focus on application of single cell analysis directly to diseases to understand mechanisms and discover potential therapeutic treatments.