Like other scientific communities all across the globe, the Single Cell Community is committed to contribute with its research to help win the fight against the COVID-19 pandemic. Please find below recent (single cell) publications and other useful resources for COVID-19 research within the Single Cell community.


Muus C, Luecken MD, Eraslan G, Sikkema L, Waghray A, Heimberg G et al.. Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics. Nat Med. 2021. doi: 10.1038/s41591-020-01227-z. Online ahead of print. PubMed PMID: 33654293

Wyler E, Mösbauer K, Franke V, Diag A, Gottula LT, Arsiè R et al.. Transcriptomic profiling of SARS-CoV-2 infected human cell lines identifies HSP90 as target for COVID-19 therapy. iScience. 2021; 24(3):102151. doi: 10.1016/j.isci.2021.102151. PubMed PMID: 33585804 

Heming M, Li X, Räuber S, Mausberg AK, Börsch AL, Hartlehnert M et al.. Neurological Manifestations of COVID-19 Feature T Cell Exhaustion and Dedifferentiated Monocytes in Cerebrospinal Fluid. Immunity. 2021 ;54(1):164-175.e6. doi: 10.1016/j.immuni.2020.12.011. PubMed PMID: 33382973

De Domenico E, Bonaguro L, Schulte-Schrepping J, Becker M, Händler K, Schultze JL. Optimized workflow for single-cell transcriptomics on infectious diseases including COVID-19. STAR Protoc. 2020 ;1(3):100233. doi: 10.1016/j.xpro.2020.100233. PubMed PMID: 33377120

Bernardes, J P, Mishra, N, Tran, F, Bahmer, T, Best, L, Blase, JI et al.Longitudinal multi-omics analyses identify responses of megakaryocytes, erythroid cells and plasmablasts as hallmarks of severe COVID-19 trajectories. Immunity. 2020;  S1074-7613(20)30504-5. doi: 10.1016/j.immuni.2020.11.017. PubMedbPMID: 33296687

Schulte-Schrepping, J, Reusch, N, Paclik, D, Baßler, K, Schlickeiser, S, Zhang, B et al.Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment. Cell. 2020;182 (6):1419-1440.e23. doi: 10.1016/j.cell.2020.08.001. PubMed PMID:32810438

Sungnak, W, Huang, N, Bécavin, C, Berg, M, Queen, R, Litvinukova, M et al.SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes. Nat Med. 2020; 26(5):681-687. doi: 10.1038/s41591-020-0868-6. PubMed PIMD:32327758

Ziegler, CGK, Allon, SJ, Nyquist, SK, Mbano, IM, Miao, VN, Tzouanas, CN et al.SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues. Cell. 2020;181 (5):1016-1035.e19. doi: 10.1016/j.cell.2020.04.035. PubMed PMID:32413319

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Hippich, M, Sifft, P, Zapardiel-Gonzalo, J, Böhmer, MM, Lampasona, V, Bonifacio, E et al.. A Public Health Antibody Screening Indicates a Marked Increase of SARS-CoV-2 Exposure Rate in Children during the Second Wave. Med (N Y). 2021; :. doi: 10.1016/j.medj.2021.03.019. PubMed PMID:33842906

Reusch, N, De Domenico, E, Bonaguro, L, Schulte-Schrepping, J, Baßler, K, Schultze, JL et al.. Neutrophils in COVID-19. Front Immunol. 2021;12 :652470. doi: 10.3389/fimmu.2021.652470. PubMed PMID:33841435

Jochum, J, Kreuels, B, Tannich, E, Huber, S, Schulze Zur Wiesch, J, Schmiedel, S et al.. Malaria in the Time of COVID-19: Do Not Miss the Real Cause of Illness. Trop Med Infect Dis. 2021;6 (2):. doi: 10.3390/tropicalmed6020040. PubMed PMID:33810597

Pritsch, M, Radon, K, Bakuli, A, Le Gleut, R, Olbrich, L, Guggenbüehl Noller, JM et al.. Prevalence and Risk Factors of Infection in the Representative COVID-19 Cohort Munich. Int J Environ Res Public Health. 2021;18 (7):. doi: 10.3390/ijerph18073572. PubMed PMID:33808249

Pombo, A, Luz, C, de Sá, C, Rodrigues, LP, Cordovil, R. Effects of the COVID-19 Lockdown on Portuguese Children’s Motor Competence. Children (Basel). 2021;8 (3):. doi: 10.3390/children8030199. PubMed PMID:33800046

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Databases, Tools and other Resources

Overview of resources for COVID-19 (single cell) research which are provided by members of the scientific community.

  • BIP! Finder for COVID-19 – aims to ease the exploration of COVID-19-related literature by enabling ranking articles
  • Cell Press Coronavirus Resource Hub – latest COVID-19 content published by Cell Press journals, including protocols and articles
  • CORD-19 – COVID-19 Open Research Dataset (Allen institute for AI) – free resource of more than 280,000 scholarly articles about the novel coronavirus for use by the global research community
  • Covid Triage – search engine developed as part of SIBiLS (Swiss Institute of Bioinformatics Literature Services) to rank the COVID-19 literature (Medline, PMC, Cord-19) according to the 9 axes of the COVoc ontology (controlled vocabulary to support literature triage for COVID-19)
  • Europe PMC COVID-19 preprints initiative – Indexing the full text of COVID-19 related preprints to make them searchable alongside peer-reviewed articles via Europe PMC
  • iSearch COVID-19 Portfolio – comprehensive, expert-curated source for publications and preprints related to COVID-19 / SARS-CoV-2, with powerful search functionality and faceting, including articles from PubMed and preprints from arXiv, bioRxiv, ChemRxiv, medRxiv, Research Square, and SSRN
  • LitCovid – curated literature hub for tracking up-to-date scientific information about the the Coronavirus, providing a central access to relevant articles in PubMed with further categorization by different research topics and geographic locations for improved access