Single-cell genomics is revolutionizing biology and medicine, combining the advantages of bulk sequencing techniques and microscopic analyses of single cells. Rapid technological advances now allow the profiling of genomes, transcriptomes and epigenomes at an unprecedented level of resolution. To harness the full potential of these developments  new computational methods specifically tailored towards the analysis of single-cell omics data are essential. Integrating efforts in all research areas involved will enhance the translation of single-cell sequencing techniques to the clinic. The single cell genomics network Germany (SCGNG) brings together  national researchers using and developing single-cell technologies to generate insights into biological systems. Its mission is to provide a collaborative platform for the exchange of both computational and experimental methods and expertise, thereby strengthening single-cell research in Germany. Connecting the German single-cell community with relevant international initiatives (such as HCA and IHEC), the SCGNG will help to address biomedical questions and foster translational research.